{"id":19142,"date":"2026-05-26T03:47:38","date_gmt":"2026-05-26T03:47:38","guid":{"rendered":"https:\/\/globalnewstoday.uk\/index.php\/2026\/05\/26\/henry-c-fung-today-it-is-time-for-the-quiet-architect-of-myeloma-biology-trisomies-oncodaily\/"},"modified":"2026-05-26T03:47:38","modified_gmt":"2026-05-26T03:47:38","slug":"henry-c-fung-today-it-is-time-for-the-quiet-architect-of-myeloma-biology-trisomies-oncodaily","status":"publish","type":"post","link":"https:\/\/globalnewstoday.uk\/index.php\/2026\/05\/26\/henry-c-fung-today-it-is-time-for-the-quiet-architect-of-myeloma-biology-trisomies-oncodaily\/","title":{"rendered":"Henry C Fung: Today, It is Time for the Quiet Architect of Myeloma Biology \u2013 Trisomies – Oncodaily"},"content":{"rendered":"

Henry C Fung<\/strong>, Chair and Professor, Department of Bone Marrow Transplant and Cellular Therapy at Fox Chase Cancer Center, shared a post on X<\/a>:
“We had talked about t(11;14), t(4;14), t(14;16) and even myc.
Today, it is time for the quiet architect of myeloma biology: TRISOMIES<\/strong>.
Not one dominant oncogene. Not genomic explosion. Just extra chromosomes – slowly turning up the volume of hundreds of survival genes at once.
Gene dosage. Cyclin D signaling. Proteostasis advantage. Marrow niche cooperation.
A biologic orchestra rather than a single guitar solo.
This may explain why many hyperdiploid myeloma<\/strong> patients can remain MGUS\/SMM for years before evolutionary escape occurs. In biology we trust.”
\"Henry
While quoting one of the previous posts<\/a>:
“We\u2019ve talked about t(11;14). We\u2019ve covered t(4;14). Today: t(14;16) myeloma.
Same disease label – Very different behavior.
Early phase (MAF-driven):<\/strong>
Niche-dependent biology.
-> IMiD \/ PI \/ Dara work well. But the story doesn\u2019t end there.
With evolution:<\/strong>
Niche-independent biology:<\/strong>
-> IMiD \/ PI less effective
->\u00a0CAR-T & bispecifics make more sense
This is the paradox – ‘<\/strong>Sticky’ early\u2026 but prone to escape later.
t(14;16) isn\u2019t just high-risk – it\u2019s an evolving disease.
Adhesion – Evolution – Escape.
Dr. Fun + G”
\"Henry
Other articles featuring Henry C Fung<\/a> on OncoDaily.<\/em>
 
OncoDaily\u2122 | \u00a9 2023 – 2025
All rights reserved. Unauthorized reproduction, distribution, or transmission of any content on OncoDaily.com is strictly prohibited. For permission requests or inquiries, please contact OncoDaily directly. By accessing and using OncoDaily.com, you acknowledge and agree to comply with this copyright notice, as well as our Privacy Policy, Editorial Policy, Cookie Policy, and Disclaimer. Continued use of this website constitutes acceptance of all such terms and policies.
Phone number: +1 978 717 48 84 <\/a>
Email: info@oncodaily.com<\/a> <\/p>\n

source<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Henry C Fung, Chair and Professor, Department of Bone Marrow Transplant and Cellular Therapy at Fox Chase Cancer Center, shared a post on X:“We had talked about t(11;14), t(4;14), t(14;16) and even myc.Today, it is time for the quiet architect of myeloma biology: TRISOMIES.Not one dominant oncogene. Not genomic explosion. Just extra chromosomes – slowly […]<\/p>\n","protected":false},"author":1,"featured_media":19143,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-19142","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science"],"_links":{"self":[{"href":"https:\/\/globalnewstoday.uk\/index.php\/wp-json\/wp\/v2\/posts\/19142","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/globalnewstoday.uk\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/globalnewstoday.uk\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/globalnewstoday.uk\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/globalnewstoday.uk\/index.php\/wp-json\/wp\/v2\/comments?post=19142"}],"version-history":[{"count":0,"href":"https:\/\/globalnewstoday.uk\/index.php\/wp-json\/wp\/v2\/posts\/19142\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/globalnewstoday.uk\/index.php\/wp-json\/wp\/v2\/media\/19143"}],"wp:attachment":[{"href":"https:\/\/globalnewstoday.uk\/index.php\/wp-json\/wp\/v2\/media?parent=19142"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/globalnewstoday.uk\/index.php\/wp-json\/wp\/v2\/categories?post=19142"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/globalnewstoday.uk\/index.php\/wp-json\/wp\/v2\/tags?post=19142"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}