{"id":17472,"date":"2026-05-19T04:44:21","date_gmt":"2026-05-19T04:44:21","guid":{"rendered":"https:\/\/globalnewstoday.uk\/index.php\/2026\/05\/19\/codon-optimization-isnt-equal-benchmarking-gene-design-for-antibody-expression-genetic-engineering-and-biotechnology-news\/"},"modified":"2026-05-19T04:44:21","modified_gmt":"2026-05-19T04:44:21","slug":"codon-optimization-isnt-equal-benchmarking-gene-design-for-antibody-expression-genetic-engineering-and-biotechnology-news","status":"publish","type":"post","link":"https:\/\/globalnewstoday.uk\/index.php\/2026\/05\/19\/codon-optimization-isnt-equal-benchmarking-gene-design-for-antibody-expression-genetic-engineering-and-biotechnology-news\/","title":{"rendered":"Codon Optimization Isn\u2019t Equal: Benchmarking Gene Design for Antibody Expression &#8211; Genetic Engineering and Biotechnology News"},"content":{"rendered":"<p>Credit: Yana Iskayeva \/ Getty Images<\/p>\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\"><\/p>\n<div class=\"wp-block-column\"><\/div>\n<p><button class=\"wp-block-malblocks-scroll-button scroll-button theme-bg\">Register Now<\/button><\/p>\n<h3 class=\"w-full text-left\">     <strong>             <\/strong> <\/h3>\n<div class=\"flex flex-row m-0-auto items-stretch justify-center flex-wrap mb-4\">\n<div id=\"presenter-card-0\"     class=\"border-none min-h-48 w-full md:w-1\/2 grow lg:w-1\/3 xl:w-1\/4  xl:max-w-1\/4 md:max-w-1\/2 lg:max-w-1\/3 presenter-card\">\n<div class=\"items-center w-full flex flex-col gap-2 align-center\">\n<div id=\"presenter-content-0\"             class=\"p-6 flex flex-col bg-white rounded-md text-center\">\n<div class=\"flex flex-col items-center grow gap-2\">\n<div class=\"!max-w-[150px] !mb-6 !overflow-hidden rounded-full aspect-square\">                     <img decoding=\"async\" src=\"https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/05\/USE-THIS-ONE_Justin-Byers-Dec-2025-e1778875450842.jpeg\" class=\"h-full w-full object-cover\"                         alt=\"Image of Justin Byers\">                 <\/div>\n<h2 class=\"!text-[16px] !leading-[24px] !font-palatino !font-bold mt-0 mb-0\">Justin Byers<\/h2>\n<h5 class=\"mt-0 !text-[15px]\"                     style=\"color: #444444\">Founder and CEO<br \/>Axio BioPharma<\/h5>\n<\/p><\/div>\n<p>             <button                 type=\"button\"                 onclick=\"presenter_modal_0.showModal()\"                 class=\"!w-auto hover:!bg-gray-100 !py-[16px] !px-[18px] self-center !mt-1 !text-xl shadow-none !text-gen-red dui-btn rounded-none border-1 !bg-white text-center !border-gen-red hover:!border-borderDark focus:!border-borderDark font-roboto! font-bold\">                 View Bio             <\/button>         <\/div>\n<\/p><\/div>\n<\/p><\/div>\n<p> <dialog id=\"presenter_modal_0\" class=\"dui-modal\">     <\/p>\n<div class=\"dui-modal-box bg-white p-0 rounded-none min-w-1\/2 w-full max-w-full  sm:max-w-5\/6 lg:max-w-[1040px]\">\n<div class=\"!pl-5 !pr-3 flex flex-row space-between w-full items-center !py-2\">\n<h3 class=\"font-normal w-full !text-gray-600 !font-roboto mb-0 py-2 !text-[20px]\">Panelist<\/h3>\n<p>             <button                 onclick=\"presenter_modal_0.close()\"                 class=\"dui-btn !highlight-none hover:!bg-white shadow-none !bg-white border-none\">                 <img decoding=\"async\" class=\"text-gray-200 mb-0\" src=\"\/wp-content\/themes\/genengnews\/assets\/svg\/icons8-close-18.svg\"                     alt=\"Close Button\">             <\/button>         <\/div>\n<div class=\"w-full bg-gray-200 h-[1px]\"><\/div>\n<div class=\"p-4 flex flex-col justify-center\">\n<div class=\"grid grid-cols-1 sm:grid-cols-[150px_1fr_1fr_1fr] mx-[7%] my-8\">\n<div class=\"flex flex-row w-full justify-center\">\n<div class=\"col-span-1 !overflow-hidden !max-w-[150px]\">                         <img decoding=\"async\" class=\"object-cover\" src=\"https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/05\/USE-THIS-ONE_Justin-Byers-Dec-2025-e1778875450842.jpeg\"                             alt=\"Image of Justin Byers\">                     <\/div>\n<\/p><\/div>\n<div class=\"flex flex-col col-span-3 sm:!ml-12 biomodal\">\n<h2 class=\"!text-[20px] !mb-4 !font-palatino !font-bold mt-0 !text-center sm:!text-left\">Justin Byers<\/h2>\n<p class=\"!text-[15px] !leading-[24px] text-justify\"                         style=\"color: #444444\">\n<p>Justin Byers is the founder and CEO of Axio BioPharma. He holds a BS in biochemistry and molecular biology from Illinois State University and has held leadership roles at Illumina, Danaher, and Fujifilm. Throughout his career, Byers has led commercial, operational, and cross-functional initiatives supporting biologics programs from early development through manufacturing. He has worked closely with scientific teams to scale workflows, improve process rigor, and align technical execution with strategic objectives. At Axio, Byers oversees corporate strategy, partnerships, and scientific direction. His focus is positioning the company at the intersection of structured data and biologics workflow execution. Axio is accelerating biologics development through mAb production services for R&amp;D while partnering with innovators and CDMOs to ensure the data required for rigorous decision making and a digitally enabled future is generated, structured, and accessible.<\/p>\n<\/p>\n<div class=\"dui-modal-action\">\n<form method=\"dialog\" class=\"bg-white\">                         <!-- if there is a button in form, it will close the modal -->                         <button                             type=\"button\"                             onclick=\"presenter_modal_0.close()\"                             class=\"!w-auto shadow-none bottom-12 right-12 sm:static !text-xl !text-gen-red dui-btn rounded-none !bg-white border-1 text-center hover:!bg-gray-100 !border-gen-red hover:!border-borderDark focus:border-borderDark !py-[16px] !px-[18px] self-center mt-1 text-6 font-roboto! font-bold\">                             Close                         <\/button>                     <\/form>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<div class=\"w-full bg-gray-200 h-[1px]\"><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<p>  <\/dialog> <\/p>\n<div id=\"presenter-card-1\"     class=\"border-none min-h-48 w-full md:w-1\/2 grow lg:w-1\/3 xl:w-1\/4  xl:max-w-1\/4 md:max-w-1\/2 lg:max-w-1\/3 presenter-card\">\n<div class=\"items-center w-full flex flex-col gap-2 align-center\">\n<div id=\"presenter-content-1\"             class=\"p-6 flex flex-col bg-white rounded-md text-center\">\n<div class=\"flex flex-col items-center grow gap-2\">\n<div class=\"!max-w-[150px] !mb-6 !overflow-hidden rounded-full aspect-square\">                     <img decoding=\"async\" src=\"https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/05\/Dan-Lin-Arlow_headshot.jpg\" class=\"h-full w-full object-cover\"                         alt=\"Image of Daniel Lin-Arlow, PhD\">                 <\/div>\n<h2 class=\"!text-[16px] !leading-[24px] !font-palatino !font-bold mt-0 mb-0\">Daniel Lin-Arlow, PhD<\/h2>\n<h5 class=\"mt-0 !text-[15px]\"                     style=\"color: #444444\">Chief Scientific Officer and Co-founder<br \/>Ansa Biotechnologies<\/h5>\n<\/p><\/div>\n<p>             <button                 type=\"button\"                 onclick=\"presenter_modal_1.showModal()\"                 class=\"!w-auto hover:!bg-gray-100 !py-[16px] !px-[18px] self-center !mt-1 !text-xl shadow-none !text-gen-red dui-btn rounded-none border-1 !bg-white text-center !border-gen-red hover:!border-borderDark focus:!border-borderDark font-roboto! font-bold\">                 View Bio             <\/button>         <\/div>\n<\/p><\/div>\n<\/p><\/div>\n<p> <dialog id=\"presenter_modal_1\" class=\"dui-modal\">     <\/p>\n<div class=\"dui-modal-box bg-white p-0 rounded-none min-w-1\/2 w-full max-w-full  sm:max-w-5\/6 lg:max-w-[1040px]\">\n<div class=\"!pl-5 !pr-3 flex flex-row space-between w-full items-center !py-2\">\n<h3 class=\"font-normal w-full !text-gray-600 !font-roboto mb-0 py-2 !text-[20px]\">Panelist<\/h3>\n<p>             <button                 onclick=\"presenter_modal_1.close()\"                 class=\"dui-btn !highlight-none hover:!bg-white shadow-none !bg-white border-none\">                 <img decoding=\"async\" class=\"text-gray-200 mb-0\" src=\"\/wp-content\/themes\/genengnews\/assets\/svg\/icons8-close-18.svg\"                     alt=\"Close Button\">             <\/button>         <\/div>\n<div class=\"w-full bg-gray-200 h-[1px]\"><\/div>\n<div class=\"p-4 flex flex-col justify-center\">\n<div class=\"grid grid-cols-1 sm:grid-cols-[150px_1fr_1fr_1fr] mx-[7%] my-8\">\n<div class=\"flex flex-row w-full justify-center\">\n<div class=\"col-span-1 !overflow-hidden !max-w-[150px]\">                         <img decoding=\"async\" class=\"object-cover\" src=\"https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/05\/Dan-Lin-Arlow_headshot.jpg\"                             alt=\"Image of Daniel Lin-Arlow, PhD\">                     <\/div>\n<\/p><\/div>\n<div class=\"flex flex-col col-span-3 sm:!ml-12 biomodal\">\n<h2 class=\"!text-[20px] !mb-4 !font-palatino !font-bold mt-0 !text-center sm:!text-left\">Daniel Lin-Arlow, PhD<\/h2>\n<p class=\"!text-[15px] !leading-[24px] text-justify\"                         style=\"color: #444444\">\n<p>Daniel Lin-Arlow, PhD, is a scientist-entrepreneur with deep expertise in synthetic biology and biophysics. Motivated by firsthand challenges in obtaining DNA constructs for metabolic engineering in graduate school, he is deeply committed to providing scientists with the DNA constructs they need for their research. As Ansa\u2019s founding CEO, Lin-Arlow grew the company from two employees in 2018 to more than 70 by 2024, raising over $130 million in venture capital and grant funding to support technology development and commercialization. He transitioned to the role of chief scientific officer in 2024, where he leads the development of new applications of the company\u2019s technologies.\u00a0Lin-Arlow received his PhD from the University of California, Berkeley for his work in Jay Keasling\u2019s lab for developing the DNA synthesis technology commercialized by Ansa. Prior to graduate school, he was a scientific associate at D.E. Shaw Research where he studied the biophysical properties of G protein-coupled receptors, including how drugs bind and modulate their activity. Dan began his scientific career at MIT, where he earned dual SB degrees in math with computer science and biology, and developed computation tools for the analysis of regulation of gene expression at the Broad Institute of MIT and Harvard. Lin-Arlow is a co-inventor of nine patent families and has co-authored scientific publications in <em>Nature, Science, Cell, PNAS<\/em>, and <em>Nature Biotechnology<\/em>.<\/p>\n<\/p>\n<div class=\"dui-modal-action\">\n<form method=\"dialog\" class=\"bg-white\">                         <!-- if there is a button in form, it will close the modal -->                         <button                             type=\"button\"                             onclick=\"presenter_modal_1.close()\"                             class=\"!w-auto shadow-none bottom-12 right-12 sm:static !text-xl !text-gen-red dui-btn rounded-none !bg-white border-1 text-center hover:!bg-gray-100 !border-gen-red hover:!border-borderDark focus:border-borderDark !py-[16px] !px-[18px] self-center mt-1 text-6 font-roboto! font-bold\">                             Close                         <\/button>                     <\/form>\n<\/p><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<div class=\"w-full bg-gray-200 h-[1px]\"><\/div>\n<\/p><\/div>\n<\/p><\/div>\n<p>  <\/dialog><\/div>\n<p>Justin Byers is the founder and CEO of Axio BioPharma. He holds a BS in biochemistry and molecular biology from Illinois State University and has held leadership roles at Illumina, Danaher, and Fujifilm. Throughout his career, Byers has led commercial, operational, and cross-functional initiatives supporting biologics programs from early development through manufacturing. He has worked closely with scientific teams to scale workflows, improve process rigor, and align technical execution with strategic objectives. At Axio, Byers oversees corporate strategy, partnerships, and scientific direction. His focus is positioning the company at the intersection of structured data and biologics workflow execution. Axio is accelerating biologics development through mAb production services for R&amp;D while partnering with innovators and CDMOs to ensure the data required for rigorous decision making and a digitally enabled future is generated, structured, and accessible.<\/p>\n<p>Daniel Lin-Arlow, PhD, is a scientist-entrepreneur with deep expertise in synthetic biology and biophysics. Motivated by firsthand challenges in obtaining DNA constructs for metabolic engineering in graduate school, he is deeply committed to providing scientists with the DNA constructs they need for their research. As Ansa\u2019s founding CEO, Lin-Arlow grew the company from two employees in 2018 to more than 70 by 2024, raising over $130 million in venture capital and grant funding to support technology development and commercialization. He transitioned to the role of chief scientific officer in 2024, where he leads the development of new applications of the company\u2019s technologies.\u00a0Lin-Arlow received his PhD from the University of California, Berkeley for his work in Jay Keasling\u2019s lab for developing the DNA synthesis technology commercialized by Ansa. Prior to graduate school, he was a scientific associate at D.E. Shaw Research where he studied the biophysical properties of G protein-coupled receptors, including how drugs bind and modulate their activity. Dan began his scientific career at MIT, where he earned dual SB degrees in math with computer science and biology, and developed computation tools for the analysis of regulation of gene expression at the Broad Institute of MIT and Harvard. Lin-Arlow is a co-inventor of nine patent families and has co-authored scientific publications in <em>Nature, Science, Cell, PNAS<\/em>, and <em>Nature Biotechnology<\/em>.<\/p>\n<div style=\"height:34px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<p><\/p>\n<div><strong>Broadcast Date:<\/strong>\u00a0<time>Thursday, June 11, 2026<\/time><\/p>\n<ul style=\"list-style-type:none;padding-left:0\">\n<li style=\"margin-bottom:0;margin-left:0\"><strong>Time:<\/strong>\u00a0<time datetime=\"2026-06-11T15:00:00.000Z\">08:00 PDT, 11:00 EDT, 15:00 GMT<\/time><\/li>\n<\/ul>\n<\/div>\n<p><\/p>\n<div style=\"height:43px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<p><\/p>\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\"><\/p>\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">Antibody expression titers are key drivers of screening efficiency in discovery, developability, manufacturing economics, and development timelines. Although it is possible to address poor antibody expression by increasing overall batch size and optimizing downstream processes, the root cause often lies in the underlying DNA sequences. Controlled benchmarking studies are helpful for systematically evaluating DNA construct design decisions that impact titers.<\/p>\n<p>In this <em>GEN<\/em> webinar, Justin Byers and Daniel Lin-Arlow, PhD, examine how enzymatic DNA synthesis and DNA construct design mitigate antibody expression challenges.<\/p>\n<p>Byers will walk through a controlled benchmarking study of codon-optimization approaches, including details of the study design and how structured, gene-to-protein workflows can help identify optimal constructs before they become downstream problems. He will show that under matched CHO and HEK293 conditions, antibody constructs codon-optimized with an AI codon language model had consistently higher transient expression titers than other approaches. The AI codon-optimized sequences contained \u201ccomplex\u201d features such as repeats and GC skew that challenge traditional gene synthesis processes but were readily manufactured by Ansa\u2019s DNA synthesis platform. These results suggest that complex sequence features can be important for optimal gene expression, which makes the ability to manufacture them as relevant as the codon strategy.<\/p>\n<p>Lin-Arlow will present Ansa\u2019s enzymatic DNA synthesis technology and the benefits to clients working on antibody production, cell and gene therapies, and other synthetic biology applications. Key takeaways include:<\/p>\n<p><\/p>\n<ul class=\"wp-block-list\"><\/p>\n<li>An AI-powered codon optimization strategy that measurably improves transient antibody expression yield<\/li>\n<p><\/p>\n<li>Why controlled side-by-side benchmarking under standardized conditions is the only reliable way to objectively evaluate DNA construct design choices<\/li>\n<p><\/p>\n<li>How integrating rigorous sequence evaluation upstream compresses timelines and reduces the risks of expression failures late in development<\/li>\n<p><\/p>\n<li>How Ansa\u2019s fully enzymatic DNA synthesis addresses complex sequences, including: High or low GC content, secondary structures, inverted terminal repeats (ITRs), and homopolymers<\/li>\n<p><\/p>\n<li>The Ansa On-Time Guarantee\u2014DNA orders shipped on time, or the complete order is free<\/li>\n<p><\/ul>\n<p><\/p>\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<p><em>A live Q&amp;A session will follow the presentation offering you a chance to pose questions to our expert panelists.<\/em><\/p>\n<p><\/p>\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<p><strong>Produced with support from:<\/strong><\/p>\n<p><\/p>\n<figure class=\"wp-block-image alignleft size-medium\"><a href=\"https:\/\/ansabio.com\/\" target=\"_blank\" rel=\" noreferrer noopener\"><img loading=\"lazy\" loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"83\" src=\"https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/05\/ANSA-BIO-Logo-Horizontal-Dark-300x83.jpg\" alt=\"ANSA Biotechnology logo\" class=\"wp-image-332482\" srcset=\"https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/05\/ANSA-BIO-Logo-Horizontal-Dark-300x83.jpg 300w, https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/05\/ANSA-BIO-Logo-Horizontal-Dark-1024x284.jpg 1024w, https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/05\/ANSA-BIO-Logo-Horizontal-Dark-768x213.jpg 768w, https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/05\/ANSA-BIO-Logo-Horizontal-Dark-1536x426.jpg 1536w, https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/05\/ANSA-BIO-Logo-Horizontal-Dark-2048x568.jpg 2048w, https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/05\/ANSA-BIO-Logo-Horizontal-Dark-1513x420.jpg 1513w, https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/05\/ANSA-BIO-Logo-Horizontal-Dark-696x193.jpg 696w, https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/05\/ANSA-BIO-Logo-Horizontal-Dark-1392x386.jpg 1392w, https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/05\/ANSA-BIO-Logo-Horizontal-Dark-1068x296.jpg 1068w, https:\/\/www.genengnews.com\/wp-content\/uploads\/2026\/05\/ANSA-BIO-Logo-Horizontal-Dark-1920x533.jpg 1920w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/a><\/figure>\n<p>             Copyright \u00a9 2026 Sage Publications or its affiliates, licensors, or contributors. All rights reserved, including those for text and data mining and training of large language models, artificial intelligence technologies, or similar technologies.         <\/p>\n<p><a href=\"https:\/\/news.google.com\/rss\/articles\/CBMiwwFBVV95cUxQYnpTUDVhc1RXSURydDAwNVVaZ1FDVmpPS0xDSUZmRUdEZ21pbGdQdEs5UkdRY1BLbFBBYUV2M2NuTHlTbzdGQk00cDRtc1ZDVFpOYnZnamdISjRtNXd6aFRTbW9qQ0pPbktyd1RTWUI1Uk9ZdG91Q2dKSjM2YjgzTGRPak9GamNDVzliNGxGQVo4bUhtZ3Q5UmNZYkpNT2o0MWh6aE9xTVlYVVJLbDJCenlnUEhUVXlDdUd5YmV1UThEUjQ?oc=5\">source<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Credit: Yana Iskayeva \/ Getty Images Register Now Justin Byers Founder and CEOAxio BioPharma View Bio Panelist Justin Byers Justin Byers is the founder and CEO of Axio BioPharma. He holds a BS in biochemistry and molecular biology from Illinois State University and has held leadership roles at Illumina, Danaher, and Fujifilm. Throughout his career, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":17473,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[9],"tags":[],"class_list":["post-17472","post","type-post","status-publish","format-standard","has-post-thumbnail","category-science"],"_links":{"self":[{"href":"https:\/\/globalnewstoday.uk\/index.php\/wp-json\/wp\/v2\/posts\/17472","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/globalnewstoday.uk\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/globalnewstoday.uk\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/globalnewstoday.uk\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/globalnewstoday.uk\/index.php\/wp-json\/wp\/v2\/comments?post=17472"}],"version-history":[{"count":0,"href":"https:\/\/globalnewstoday.uk\/index.php\/wp-json\/wp\/v2\/posts\/17472\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/globalnewstoday.uk\/index.php\/wp-json\/wp\/v2\/media\/17473"}],"wp:attachment":[{"href":"https:\/\/globalnewstoday.uk\/index.php\/wp-json\/wp\/v2\/media?parent=17472"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/globalnewstoday.uk\/index.php\/wp-json\/wp\/v2\/categories?post=17472"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/globalnewstoday.uk\/index.php\/wp-json\/wp\/v2\/tags?post=17472"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}