Celia Diez de los Rios: From Single Mutations to Tumour Heterogeneity in Cancer Biology – Oncodaily

Celia Diez de los Rios, Lecturer at the University of Navarra, Spain, Board Member at From Testing to Targeted Treatments (FT3), Oncology Advanced Nurse Practitioner, Research Fellow at the University of Glasgow, shared a post on LinkedIn:
“More than two decades ago, Hanahan and Weinberg described the Hallmarks of Cancer, giving oncology a shared language to understand how tumours grow, survive, and evolve. For many of us, this framework shaped how we first learned cancer biology. So complicated to understand but really showed you the ‘why’ of the treatments.
Today, the question is no longer only what cancer is, but how deeply we can understand its complexity.
We are moving from identifying single mutations to exploring tumour heterogeneity through multi-omic profiling. Cancer is increasingly understood not as isolated malignant cells, but as an ecosystem.
This has changed cancer treatment, precision medicine, co-targeting: combining therapies that address multiple biological capabilities simultaneously to overcome resistance and achieve more durable responses.
This, as every advance requires multidisciplinary collaboration. Genomic literacy across the workforce. Progress happens when biology, technology, and human care advance together.
Read Hallmarks of cancer-Then and now, and beyond from 2026 at:  10.1016/j.cell.2025.12.049.”
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